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Estimula la formación de células del páncreas y permitiría tratar esta patología con inyecciones semanales o incluso mensuales
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Month: abril 2013
Potential Diabetes Breakthrough
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HSCI Co-Director Doug Melton and postdoctoral fellow Peng Yi have discovered a hormone that holds promise for a dramatically more effective treatment of type…
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Organovo Describes First Fully Cellular 3D Bioprinted Liver Tissue
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We have achieved excellent function in a fully cellular 3D human liver tissue. With Organovo’s 3D bioprinted liver tissues, we have demonstrated the power of bioprinting to create functional human tissue that replicates human biology better than what has come before.
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Presentaciones Jornada EEA Grants (16/04/2013 – Sinaval, Bilbao)
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EEA Grants: presentaciones de la Jornada sobre Ayudas en Investigación y Desarrollo en el sector de las Energías Renovables
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Descubren una hormona que podría revolucionar el tratamiento de la diabetes
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Estimula la formación de células del páncreas y permitiría tratar esta patología con inyecciones semanales o incluso mensuales
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Más de cincuenta empresas participan en un encuentro sobre innovación tecnológica en la sanidad
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La Consejería de Sanidad, a través de la Dirección General de Innovación Sanitaria, con la colaboración de la Fundación Prodintec, ha organizado el primer encuentro Innosalud, que comienzo este jueves, y en el que participarán más de medio centenar…
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Microfluidics sector poised for 23% growth
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Contributed by Frédéric Breussin, Business Unit Manager Microfluidics & Medical Technologies, Yole Développement Heavy recent investment by big players and significant new technologies now pois…
Francisco J. Menéndez González‘s insight:
Interesante informe que tiene en cuenta el mercado importante aspecto a la hora de plantearse un desarrollo que en el paper puede tener sentido , pero que lo pierde si no hay mercado que lo absorba al final del proceso.
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Hundreds of biochemical analyses on a single microfluidic device
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Scientists at EPFL and the University of Geneva have developed a microfluidic device smaller than a domino that can simultaneously measure up to 768 biomolecular interactions.
Inside our cells in the body, molecules are constantly binding and separating from one another. It’s this game of constant flux that drives gene expression asides essentially every other biological process. Understanding the specific details of how these interactions take place is thus crucial to our overall understanding of the fundamental mechanisms of living organisms. There are millions of possible combinations of molecules, however; determining all of them would be a Herculean task.
Various tools have been developed to measure the degree of affinity between a strand of DNA and its transcription factor. They provide an indication of the strength of the affinity between them. Commercial devices, however, have one main drawback: many preliminary manipulations are necessary before an experiment can be carried out, and even then, the experiment can only focus on a dozen interactions at a time.
As part of his doctoral research at the California Institute of Technology (Caltech), Sebastian Maerkl designed a device that he named “MITOMI” — a small device containing hundreds of microfluidic channels equipped with pneumatic valves. The new version, “k-MITOMI,” was developed in the context of the SystemsX.ch RTD DynamiX in cooperation with the University of Geneva.
k-MITOMI has 768 chambers, each one with a valve that allows DNA and transcription factors to interact in a very carefully controlled manner. “In traditional methods, we generally manage to determine if an interaction takes place or not, and then we restart the experiment with another gene or another transcription factor,” Maerkl explains. “Our device goes much further, because it allows us to measure the affinity and kinetics of the interaction.”
The strength of the device lies in a sort of “push-button” in its microreactors. A protein substrate is immobilized on the device; above it circulates a solution containing DNA moelcules. The push-button is activated at regular intervals of a few milliseconds, trapping protein-DNA complexes that form on the surface of the device. “Then we close the lid, and fluorescence reveals the exact number of bound molecules,” explains Maerkl. “We can also observe how long these molecules remain bound.”
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Micro 3D Printer Creates Tiny Structures in Seconds
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Nanoscribe, a spin-off from the Karlsruhe Institute of Technology in Germany, has developed a tabletop 3D microprinter that can create complicated microstructures 100 times faster than is possible today. «If something took one hour to make, it now takes one minute,» says Michael Thiel, chief scientific officer at Nanoscribe.
While 3D printing of toys, iPhone covers and jewelry continues to grab headlines, much of 3D printing’s impact could be at a much smaller scale. Micrometer-scale printing has shown promise for making medical and electronic devices. Thiel says it should be possible to speed up his company’s microprinting technique even more in the future. Nanoscribe plans to start selling its machine in the second half of this year.
Printing microstructures with features a few hundred nanometers in size could be useful for making heart stents, microneedles for painless shots, gecko adhesives, parts for microfluidics chips, and scaffolds for growing cells and tissue. Another important application could be in the electronics industry, where patterning nanoscale features on chips currently involves slow, expensive techniques. 3D printing would quickly and cheaply yield polymer templates that could be used to make metallic structures.
So far, 3D microprinting has been used only in research laboratories because it’s pretty slow. In fact, many research labs around the world use Nanoscribe’s first-generation printer. The new, faster machine will also find commercial use. Thiel says numerous medical, life sciences, and nanotechnology companies are interested in the new machine. «I’m positive that with the faster throughput we get with this new tool, it might have an industrial breakthrough very soon,» he says.
The technology behind most 3D microprinters is called two-photon polymerization. It involves focusing tiny, ultrashort pulses from a near-infrared laser on a light-sensitive material. The material polymerizes and solidifies at the focused spots. As the laser beam moves in three dimensions, it creates a 3D object.
Today’s printers, including Nanoscribe’s present system, keep the laser beam fixed and move the light-sensitive material along three axes using mechanical stages, which slows down printing. To speed up the process, Nanoscribe’s new tool uses a tiny moving mirror to reflect the laser beam at different angles. Thiel says generating multiple light beams with a microlens array could make the process even faster.
The smallest features that can be created using the Nanoscribe printer measure about 30 nanometers, says Julia Greer, professor of materials science at the California Institute of Technology.
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Los diabéticos piden a Sanidad que erradique la reutilización de agujas
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Canarias, Murcia y Comunidad Valenciana son las únicas CCAA que dispensan el número suficiente de agujas
Francisco J. Menéndez González‘s insight:
Práctica muy extendida. si un diabético a de pincharse 4 veces al día (dos tipos de insulina), lo común es que utilice una aguja por día. Importante retirarla del septum del bolígrafo después de cada pinchazo.
Lo ideal, el uso de una aguja por cada pinchazo.
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